About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Scn4atm1.1Cann
Targeted Allele Detail
Nomenclature
Symbol: Scn4atm1.1Cann
Name: sodium channel, voltage-gated, type IV, alpha; targeted mutation 1.1, Stephen C Cannon
MGI ID: MGI:5301528
Synonyms: R669Hm, SCN4AR669H
Gene: Scn4a  Location: Chr11:106318592-106353288 bp, - strand  Genetic Position: Chr11, 68.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 13 was replaced with an FRT-flanked neo cassette and a floxed exon 13 in which nucleotide substitutions (CGT to CAC) resulted in the amino acid substitution of histidine for arginine at position 669 (R669H). Two additional silent polymorphisms were inserted at codon 661 (GTG to GTA) and 662 (CTC to CTG). Flp-mediated recombination removed the neo cassette. (J:178228)
Construction of the Scn4atm1.1Cann knockin allele
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn4a Mutation:  9 strains or lines available
References
Original:  J:178228 Wu F, et al., A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis. J Clin Invest. 2011 Oct 3;121(10):4082-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory