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Targeted Allele Detail
Symbol: Scn4atm1.1Cann
Name: sodium channel, voltage-gated, type IV, alpha; targeted mutation 1.1, Stephen C Cannon
MGI ID: MGI:5301528
Synonyms: R669Hm, SCN4AR669H
Gene: Scn4a  Location: Chr11:106318592-106353288 bp, - strand  Genetic Position: Chr11, 68.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:178228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 13 was replaced with an FRT-flanked neo cassette and a floxed exon 13 in which nucleotide substitutions (CGT to CAC) resulted in the amino acid substitution of histidine for arginine at position 669 (R669H). Two additional silent polymorphisms were inserted at codon 661 (GTG to GTA) and 662 (CTC to CTG). Flp-mediated recombination removed the neo cassette. (J:178228)
Construction of the Scn4atm1.1Cann knockin allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn4a Mutation:  11 strains or lines available
Original:  J:178228 Wu F, et al., A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis. J Clin Invest. 2011 Oct 3;121(10):4082-94
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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The Jackson Laboratory