Mthfr^tm3Rzn
Targeted Allele Detail

Summary

• Symbol: Mthfr^tm3Rzn
• Name: methylenetetrahydrofolate reductase; targeted mutation 3, Rima Rozen
• MGI ID: MGI:5301339
• Synonyms: TG-down
• Gene: Mthfr Location: Chr4:148123534-148144008 bp, + strand Genetic Position: Chr4, 78.67 cM
• Alliance: Mthfr^tm3Rzn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178814
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous downstream promoter (1793 bp) driving expression of lacZ and an Hprt minigene were inserted replaced the endogenous gene. (J:178814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mthfr Mutation: 70 strains or lines available

Notes

ES cell line = Hprt-BPES5

References

• Original: J:178814 Pickell L, et al., Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation. Mamm Genome. 2011 Dec;22(11-12):635-47
• All: 1 reference(s)