Zbtb1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Zbtb1^m1Btlr
• Name: zinc finger and BTB domain containing 1; mutation 1, Bruce Beutler
• MGI ID: MGI:5300200
• Synonyms: Zbtb1^C74R, Zbtb1^scanT
• Gene: Zbtb1 Location: Chr12:76417040-76443724 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Zbtb1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to C transition at position 15196 in the Genbank genomic region NC_000078 for the Zbtb1 gene on Chromosome 12 (77.471-77.498 Mb (+)). The mutation corresponds to nucleotide 701 of the Zbtb1 transcript in exon 2 of 2 total exons. The mutation results in a cysteine to arginine substitution at amino acid 74 of the ZBTB1 protein. (J:178820)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbtb1 Mutation: 115 strains or lines available

References

• Original: J:178820 Siggs OM, et al., ZBTB1 is a determinant of lymphoid development. J Exp Med. 2012 Jan 16;209(1):19-27
• All: 2 reference(s)