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Clec9atm1.1Crs
Targeted Allele Detail
Nomenclature
Symbol: Clec9atm1.1Crs
Name: C-type lectin domain family 9, member a; targeted mutation 1.1, Caetano Reis e Sousa
MGI ID: MGI:5298406
Synonyms: Clec9agfp
Gene: Clec9a  Location: Chr6:129385825-129401726 bp, + strand  Genetic Position: Chr6, 63.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178441
Parent Cell Line:  S6B6 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace the C-type lectin domain family 9, member a (Clec9a) coding region with a farnesylated form of enhanced green fluorescent protein (EGFP), a polyadenylation signal, and a loxP-flanked neomycin (neo) resistance cassette. Cre-mediated recombination removed the neo cassette. (J:147472)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Clec9a Mutation:  18 strains or lines available
Notes
The expression of NK1.1 (Klrb1c) is linked to Clec9a deficiency in homozygous mice, indicating that the homologous recombination step targeted the chromosome of C57BL/6J origin.
References
Original:  J:178441 Reis e Sousa C, Direct Data Submission 2011/12/16. MGI Direct Data Submission. 2011;
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory