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Tg(CAG-cat,-Dcn*)#Debi
Transgene Detail
Nomenclature
Symbol: Tg(CAG-cat,-Dcn*)#Debi
Name: transgene insertion, David E Birk
MGI ID: MGI:5298093
Synonyms: 925delTDcn
Transgene: Tg(CAG-cat,-Dcn*)#Debi  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CAG-cat,-Dcn*)#Debi expresses 1 gene
 
Mutation detailsThis transgene consists of the ubiquitous CAG promoter followed by a floxed chloramphenicol acetyltransferase (cat) gene and a mutant murine Dcn cDNA with a single base pair deletion at position 952 (delT) resulting in a frameshift mutation and truncation of the C terminal 33 amino acids. The mutation at position 952 in the mouse gene is comparable to the mutation in position 967 in the human gene seen in patients with congenital stromal corneal dystrophy. Cre mediated recombination results in expression of the mutant mouse cDNA. (J:177392)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:177392 Chen S, et al., Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am J Pathol. 2011 Nov;179(5):2409-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory