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Transgene Detail
Symbol: Tg(CAG-cat,-Dcn*)#Debi
Name: transgene insertion, David E Birk
MGI ID: MGI:5298093
Synonyms: 925delTDcn
Transgene: Tg(CAG-cat,-Dcn*)#Debi  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(CAG-cat,-Dcn*)#Debi expresses 1 gene
Mutation detailsThis transgene consists of the ubiquitous CAG promoter followed by a floxed chloramphenicol acetyltransferase (cat) gene and a mutant murine Dcn cDNA with a single base pair deletion at position 952 (delT) resulting in a frameshift mutation and truncation of the C terminal 33 amino acids. The mutation at position 952 in the mouse gene is comparable to the mutation in position 967 in the human gene seen in patients with congenital stromal corneal dystrophy. Cre mediated recombination results in expression of the mutant mouse cDNA. (J:177392)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:177392 Chen S, et al., Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am J Pathol. 2011 Nov;179(5):2409-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory