Tg(Alb-F8)EBmre
Transgene Detail

Summary

• Symbol: Tg(Alb-F8)EBmre
• Name: transgene insertion E, Birgit M Reipert
• MGI ID: MGI:5297954
• Transgene: Tg(Alb-F8)EBmre Location: unknown Genetic Position: Chr3, Syntenic
• Alliance: Tg(Alb-F8)EBmre page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-F8)EBmre expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  F8 (2157)

  F8	(MGI:88383)

• Mutation details: The promoter drives liver-specific expression of the human cDNA with a poly A signal derived from the human growth hormone and alpha-fetoprotein enhancer elements. Lines E (one insertion on chromosome 3H3) and G (one insertion on chromosome XA6) were generated. Line E does not elicite an antibody response while line G elicites the highest level of antibody response. Protein expression is detected in various organs but not in the circulation. (J:176909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:176909 van Helden PM, et al., Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model. Blood. 2011 Sep 29;118(13):3698-707
• All: 1 reference(s)