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Sirt5tm1.1Ics
Targeted Allele Detail
Nomenclature
Symbol: Sirt5tm1.1Ics
Name: sirtuin 5; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5297911
Gene: Sirt5  Location: Chr13:43370710-43395202 bp, + strand  Genetic Position: Chr13, 21.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177830
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was flanked by loxP sites. Cre-mediated recombination removed exon 4. The absence of protein expression was confirmed by western blot analysis. (J:177830)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt5 Mutation:  15 strains or lines available
References
Original:  J:177830 Du J, et al., Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11;334(6057):806-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory