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Targeted Allele Detail
Symbol: Map2k7tm1Rjd
Name: mitogen-activated protein kinase kinase 7; targeted mutation 1, Roger J Davis
MGI ID: MGI:5297854
Synonyms: mkk7fl
Gene: Map2k7  Location: Chr8:4238740-4247897 bp, + strand  Genetic Position: Chr8, 1.99 cM, cytoband A1.1
Germline Transmission:  Earliest citation of germline transmission: J:178060
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exons 4-7 were floxed. (J:186492)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k7 Mutation:  5 strains or lines available
Original:  J:178060 Mazzitelli S, et al., The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo. J Neurosci. 2011 Nov 23;31(47):16969-76
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory