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Kittm1.1Sraf
Targeted Allele Detail
Nomenclature
Symbol: Kittm1.1Sraf
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Shahin Rafii
MGI ID: MGI:5297728
Synonyms: c-Kit lox66-71
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178071
Parent Cell Line:  C2J (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA construct containing a lox66 site, inverted GFP gene, lox71, and FRT-flanked neo cassette was inserted between exon 8 and exon 9. Flp-mediated recombination removed the neo cassette. (J:178071)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  149 strains or lines available
References
Original:  J:178071 Kimura Y, et al., c-Kit-Mediated Functional Positioning of Stem Cells to Their Niches Is Essential for Maintenance and Regeneration of Adult Hematopoiesis. PLoS One. 2011;6(10):e26918
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory