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Targeted Allele Detail
Symbol: Aqp4tm1.1Geno
Name: aquaporin 4; targeted mutation 1.1, Genoway
MGI ID: MGI:5297539
Synonyms: Aqp4flox
Gene: Aqp4  Location: Chr18:15389394-15403684 bp, - strand  Genetic Position: Chr18, 8.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:177412
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 1 through 3 floxed. (J:177412)
Generation of the conditional Aqp4tm1.1Geno allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp4 Mutation:  16 strains or lines available
Original:  J:177412 Haj-Yasein NN, et al., Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17815-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory