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Transgene Detail
Symbol: Tg(Vsx2-cre)2690Chow
Name: transgene insertion 2690, Robert L Chow
MGI ID: MGI:5297524
Synonyms: Vsx2-5.3-PRE-Cre
Transgene: Tg(Vsx2-cre)2690Chow  Location: unknown  
Strain of Origin:  C57BL/6 x C3H
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsCre recombinase cDNA was cloned downstream of a 5.3kb upstream region of the Vsx2 gene. A 1.9 kb region containing a 164 bp bipolar enhancer was cloned 5' of the 5.3 kb region. An SV40 polyadenylation sequence was inserted downstream of cre. The 1.9 kb region has been identified as a putative retinal enhancer (PRE) and lies within a conserved non-coding region that is within the breakpoint of the Vsx2 (ocular retardation 2J) mutation. 6 founder lines carried the transgene, with 4 (2690, 2695, 2700, and 2717) exhibiting cre expression detected by immunolabeling. (J:178063)
 Tissue activity of this recombinase allele
Driver: Vsx2     Summary of all recombinase alleles driven by Vsx2.

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:178063 Nickerson PE, et al., A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors. PLoS One. 2011;6(10):e27145
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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