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Pglyrp3tm1Rdz
Targeted Allele Detail
Nomenclature
Symbol: Pglyrp3tm1Rdz
Name: peptidoglycan recognition protein 3; targeted mutation 1, Roman Dziarski
MGI ID: MGI:5297106
Gene: Pglyrp3  Location: Chr3:92014583-92031582 bp, + strand  Genetic Position: Chr3, 40.14 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178054
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 5 were replaced with a neo cassette. Quantitative RT-PCR confirmed the absence of transcript expression. (J:178053, J:178054)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pglyrp3 Mutation:  11 strains or lines available
References
Original:  J:178054 Saha S, et al., PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe. 2009 Feb 19;5(2):137-50
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory