Tg(CD4-Tcra/EGFP,Tcrb)#Mfk
Transgene Detail
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Symbol: |
Tg(CD4-Tcra/EGFP,Tcrb)#Mfk |
Name: |
transgene insertion, Matthew F Krummel |
MGI ID: |
MGI:5296834 |
Synonyms: |
OT-I-GFP Tg |
Transgene: |
Tg(CD4-Tcra/EGFP,Tcrb)#Mfk Location: unknown
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Alliance: |
Tg(CD4-Tcra/EGFP,Tcrb)#Mfk page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CD4-Tcra/EGFP,Tcrb)#Mfk expresses
2 genes
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Mutation details: The original OT-I transgenic constructs were obtained from F. Carbone (University of Melbourne, Melbourne, Victoria, Australia). The OT-Ialpha chain was tagged on the C terminus with a 20-aa flexible linker and a single enhanced GFP using standard molecular cloning techniques and was expressed under the CD4 enhancer and promoter without the silencer. The OT-Ibeta chain was expressed under its endogenous promoter.
(J:177978)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:177978 Friedman RS, et al., Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22;207(12):2733-49 |
All: |
1 reference(s) |
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