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Targeted Allele Detail
Symbol: Tfap4tm1.1Litt
Name: transcription factor AP4; targeted mutation 1.1, Dan R Littman
MGI ID: MGI:5296820
Gene: Tfap4  Location: Chr16:4544661-4559854 bp, - strand  Genetic Position: Chr16, 2.45 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:176461
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 through 4 were replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on thymocytes. (J:176461)
Generation of Tfap4 deficient mice
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfap4 Mutation:  84 strains or lines available
Original:  J:176461 Egawa T, et al., Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14873-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory