Atp1a2^tm4.1Ling
Targeted Allele Detail

Summary

• Symbol: Atp1a2^tm4.1Ling
• Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 4.1, Jerry B Lingrel
• MGI ID: MGI:5296814
• Synonyms: alpha2^FLOX
• Gene: Atp1a2 Location: Chr1:172099276-172125631 bp, - strand Genetic Position: Chr1, 79.6 cM
• Alliance: Atp1a2^tm4.1Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177051
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and left exon 1 floxed. (J:177051)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a2 Mutation: 61 strains or lines available

References

• Original: J:177051 Rindler TN, et al., Knockout of the Na,K-ATPase {alpha}2-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1396-404
• All: 5 reference(s)