Men1^tm2.1Mmey
Targeted Allele Detail

Summary

• Symbol: Men1^tm2.1Mmey
• Name: multiple endocrine neoplasia 1; targeted mutation 2.1, Matthew Meyerson
• MGI ID: MGI:5296656
• Synonyms: Men1^f, Men1^lox
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm2.1Mmey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88588
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 3 through 6 floxed. This allele was used to generate Men1^tm1Mmey. (J:88588)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm2.1Mmey

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:88588 Hughes CM, et al., Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004 Mar 27;13(4):587-97
• All: 9 reference(s)