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Targeted Allele Detail
Symbol: Juptm1.1Shou
Name: junction plakoglobin; targeted mutation 1.1, Weinian Shou
MGI ID: MGI:5296511
Synonyms: Jupf
Gene: Jup  Location: Chr11:100368958-100397763 bp, - strand  Genetic Position: Chr11, 63.47 cM
Germline Transmission:  Earliest citation of germline transmission: J:177567
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette flanked by two loxP sites and a fragment including part of Jup introns 2-6 with a third loxP site inserted into intron 5 was engineered downstream of the neomycin selection cassette. The neomycin cassette was removed by breeding with Tg(EIIa-cre)C5379Lmgd mice, leaving exons 3-5 floxed (J:177567)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jup Mutation:  147 strains or lines available
Original:  J:177567 Li D, et al., Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
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