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Juptm1.1Shou
Targeted Allele Detail
Nomenclature
Symbol: Juptm1.1Shou
Name: junction plakoglobin; targeted mutation 1.1, Weinian Shou
MGI ID: MGI:5296511
Synonyms: Jupf
Gene: Jup  Location: Chr11:100368958-100397763 bp, - strand  Genetic Position: Chr11, 63.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177567
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette flanked by two loxP sites and a fragment including part of Jup introns 2-6 with a third loxP site inserted into intron 5 was engineered downstream of the neomycin selection cassette. The neomycin cassette was removed by breeding with Tg(EIIa-cre)C5379Lmgd mice, leaving exons 3-5 floxed (J:177567)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jup Mutation:  129 strains or lines available
References
Original:  J:177567 Li D, et al., Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory