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Fn1tm2.1Ref
Targeted Allele Detail
Nomenclature
Symbol: Fn1tm2.1Ref
Name: fibronectin 1; targeted mutation 2.1, Reinhard Fassler
MGI ID: MGI:5296500
Synonyms: FNRGE
Gene: Fn1  Location: Chr1:71585520-71653200 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177821
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsA C1238G mutation in exon 30 results in an aspartic to glutamic acid change altering the RGD motif to RGE. A floxed neomycin resistance cassette was inserted in intron 30 and subsequently removed from properly targeted mice by cre excision. (J:177821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  80 strains or lines available
References
Original:  J:177821 Takahashi S, et al., The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007 Jul 2;178(1):167-78
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory