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Brd1tm1Hko
Targeted Allele Detail
Nomenclature
Symbol: Brd1tm1Hko
Name: bromodomain containing 1; targeted mutation 1, Haruhiko Koseki
MGI ID: MGI:5296490
Gene: Brd1  Location: Chr15:88687034-88734228 bp, - strand  Genetic Position: Chr15, 44.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177092
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on E12.5 embryo extracts. (J:177092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brd1 Mutation:  80 strains or lines available
References
Original:  J:177092 Mishima Y, et al., The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood. 2011 Sep 1;118(9):2443-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory