Lrp2bp^{tm2e(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lrp2bp^{tm2e(KOMP)Wtsi}
• Name: Lrp2 binding protein; targeted mutation 2e, Wellcome Trust Sanger Institute
• MGI ID: MGI:5296113
• Gene: Lrp2bp Location: Chr8:46463639-46482515 bp, + strand Genetic Position: Chr8, 25.99 cM, cytoband B2
• IMPC: Lrp2bp gene page

Mutation origin

• Mutant Cell Lines: EPD0730_5_G05, EPD0858_4_B01, EPD0858_4_B02, EPD0858_4_B03, EPD0858_4_C04, EPD0858_4_G02
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Pgk_P
• Mutation details: The L1L2_Pgk_P cassette was inserted at position 46464557 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp2bp Mutation: 18 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)