Dlx1tm1(cre/ERT2)Zjh
Targeted Allele Detail
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Symbol: |
Dlx1tm1(cre/ERT2)Zjh |
Name: |
distal-less homeobox 1; transgene insertion 1, Z Josh Huang |
MGI ID: |
MGI:5295937 |
Synonyms: |
Dlx1-CreER, Dlx1-CreER-KI, Dlx1-CreERT2, Dlx1-CreERT2-KI |
Gene: |
Dlx1 Location: Chr2:71358457-71364325 bp, + strand Genetic Position: Chr2, 42.61 cM
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Alliance: |
Dlx1tm1(cre/ERT2)Zjh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:151755
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Parent Cell Line: |
v6.5 (ES Cell)
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Strain of Origin: |
(C57BL/6 x 129S4/SvJae)F1
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Project Collection: |
Neuroscience Blueprint cre
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Dlx1tm1(cre/ERT2)Zjh expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Dlx1 (MGI:94901) |
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Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene, an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the distal-less homeobox 1 locus (Dlx1). The construct was electroporated into (C57BL/6 x 129S4Sv/Jae)-derived V6.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with C57BL/6 mice to originate the colony. The mutation is predicted to result in a null allele. Tamoxifen-inducible Cre recombinase activity recapitulates the endogenous Dlx1 expression pattern, Following tamoxifen administration, Cre recombinase activity is observed in Dlx1 positive cortical GABAergic neurons, striatal neurons, and olfactory neurons.
(J:151755)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Dlx1
(mouse)
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Original: |
J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009; |
All: |
12 reference(s) |
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