Flt4^tm1.1Yhe
Targeted Allele Detail

Summary

• Symbol: Flt4^tm1.1Yhe
• Name: FMS-like tyrosine kinase 4; targeted mutation 1.1, Yulong He
• MGI ID: MGI:5295071
• Synonyms: Vegfr3^Flox
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm1.1Yhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177405
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 4 through 6 floxed. (J:177405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 76 strains or lines available

References

• Original: J:177405 Zhang L, et al., VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010 Dec;20(12):1319-31
• All: 2 reference(s)