Pmel^tm1Sson
Targeted Allele Detail

Summary

• Symbol: Pmel^tm1Sson
• Name: premelanosome protein; targeted mutation 1, Leif Andersson
• MGI ID: MGI:5294791
• Synonyms: Pmel^loxP
• Gene: Pmel Location: Chr10:128540064-128556107 bp, + strand Genetic Position: Chr10, 77.13 cM
• Alliance: Pmel^tm1Sson page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177116
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exons 2 and 3 were floxed and an FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. (J:177116)

Strategy for the generation of the Pmel^tm1Sson and Pmel^tm1.1Sson alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmel Mutation: 36 strains or lines available

References

• Original: J:177116 Hellstrom AR, et al., Inactivation of pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet. 2011 Sep;7(9):e1002285
• All: 1 reference(s)