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Transgenic Allele Detail
Symbol: Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Name: tribbles homolog 2 (Drosophila); transgene insertion 2.1, Ingenium Pharmaceuticals
MGI ID: MGI:5294354
Synonyms: TBA2.1
Gene: Trib2  Location: Chr12:15791727-15816877 bp, - strand  Genetic Position: Chr12, 7.25 cM
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into position 15.5-16.5 Mbp (based on NCBI Build 36 ) on chromosome 12 resulting in deletion of Trib2. Maximal transgene expression was seen between P12 and P28. (J:176575)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trib2 Mutation:  11 strains or lines available
Original:  J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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