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Transgene Detail
Symbol: Tg(Thy1-APP*)2.2Ingm
Name: transgene insertion 2.2, Ingenium Pharmaceuticals
MGI ID: MGI:5294353
Synonyms: TBA2.2
Transgene: Tg(Thy1-APP*)2.2Ingm  Location: unknown  Genetic Position: Chr12, Syntenic
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-APP*)2.2Ingm expresses 1 gene
Mutation detailsThe Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into Chr. 12 at 53.5 Mbp with a 2-4 kbp deletion. No effect on the expression of neighboring genes (Heatr5a, Arhgap5 and Akap6) was detected. Maximal transgene expression was seen between P12 and P28. (J:176575)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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