Mirc21^tm1.2Ayn
Targeted Allele Detail

Summary

• Symbol: Mirc21^tm1.2Ayn
• Name: microRNA cluster 21, including Mir34c through Mir34b; targeted mutation 1.2, Alexander Yu Nikitin
• MGI ID: MGI:5293763
• Synonyms: mir-34b/c^KO, Mir34b/Mir34c^tm1Hher, Mirc21^tm1Hher
• Gene: Mirc21 Location: Chr9:51014334-51014945 bp Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175978
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the microRNA. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette with a 3' loxP site inserted downstream of the microRNA. Cre-mediated recombination removed the microRNA sequence.

Tumor Data

List all tumor models in MMHCdb carrying Mirc21^tm1.2Ayn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc21 Mutation: 5 strains or lines available

References

• Original: J:175978 Hwang CI, et al., Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14240-5
• All: 3 reference(s)