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Tg(MAPT*V337M)1Gds
Transgene Detail
Nomenclature
Symbol: Tg(MAPT*V337M)1Gds
Name: transgene insertion 1, Gerard Schellenberg
MGI ID: MGI:5293607
Synonyms: hT-PAC-337M
Transgene: Tg(MAPT*V337M)1Gds  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MAPT*V337M)1Gds expresses 1 gene
 
Mutation detailsThe transgenic construct contains the 201 kb P1 artificial chromosome (PAC) 61D6 and includes 5 kb of sequence upstream of the human MAPT promoter and an additional 62 kb downstream of the 3' end of MAPT. The downstream segment also contains the 3' end of the gene KIAA1267, however, human MAPT is the only complete gene in the PAC . The construct includes the mutation V337M in exon 12 representing an GTG to ATG nucleotide substitution. This mutation results in an amino acid substitution of methionine for valine at position 337. Line 1 was generated. (J:152671)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:152671 McMillan P, et al., Tau isoform regulation is region- and cell-specific in mouse brain. J Comp Neurol. 2008 Dec 20;511(6):788-803
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory