Mapk1^tm1.2Kuta
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm1.2Kuta
• Name: mitogen-activated protein kinase 1; targeted mutation 1.2, Kunio Takishima
• MGI ID: MGI:5293422
• Synonyms: ERK2^fl, Erk2^flox(Neo-)
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm1.2Kuta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171965
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neo cassette was inserted in reverse direction into intron 1 and an additional loxP site was inserted into intron 3. Cre mediated recombination removed the neo cassette. (J:125594, J:176051)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 40 strains or lines available

References

• Original: J:171965 Imamura O, et al., Analysis of extracellular signal-regulated kinase 2 function in neural stem/progenitor cells via nervous system-specific gene disruption. Stem Cells. 2008 Dec;26(12):3247-56
• All: 11 reference(s)