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Ssttm1.2(tTA2)Hze
Targeted Allele Detail
Nomenclature
Symbol: Ssttm1.2(tTA2)Hze
Name: somatostatin; targeted mutation 1.2, Hongkui Zeng
MGI ID: MGI:5292254
Synonyms: SST-tTA2-D, SST-tTA2-DELTA, SST-tTA2-deltaNEO
Gene: Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176570
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Transactivator)
Mutation:    Insertion
 
Mutation detailsA targeting vector used to insert a synthetic modified tetracycline-regulated transactivator (tTA2S) gene and 3' UTR region of the somatostatin exon 2 into the ATG transcriptional start site of the somatostatin gene (Sst). Specifically, the targeting vector was designed with (from 5' to 3') an frt3 site, a Cre recombinase gene, a bovine growth hormone polyA sequence, a second frt3 site, a tTA2S gene, the 3' UTR region from somatostatin exon 2, an AttB site, PGK-Neo-polyA cassette, an frt5 site, an RNA splice acceptor, the 3' portion of the hygromycin gene with SV40 polyA signal, and an AttP site. (J:176570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sst Mutation:  28 strains or lines available
References
Original:  J:176570 Zeng H, Direct Data Submission 2011/10/17. MGI Direct Data Submission. 2011;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory