Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Jens C Bruning |
MGI ID: |
MGI:5290071 |
Synonyms: |
miR-143DOX |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr page
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Allele Type: |
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Targeted (Inducible, Knockdown) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr involves 1 genes/genome features (Mir143)
View all
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Mutation details: A construct containing a short hairpin RNA targeting Mir143 driven by the H1/tetO operator fusion promoter followed by a CAG promoter driving expression of the tetR regulatory cassette was inserted into the locus by flp-mediated recombination via RMCE with Gt(ROSA)26Sortm1(CAG-flpe)Arte. Doxycycline-treatment is required to activate the expression of the shRNA.
(J:176266)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:176266 Jordan SD, et al., Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 2011 Apr;13(4):434-46 |
All: |
1 reference(s) |
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