Tg(tetO-SNCA)7Vle
Transgene Detail

Summary

• Symbol: Tg(tetO-SNCA)7Vle
• Name: transgene insertion 7, Virginia M-Y Lee
• MGI ID: MGI:5289965
• Synonyms: tetP-WTapha-syn
• Transgene: Tg(tetO-SNCA)7Vle Location: unknown
• Alliance: Tg(tetO-SNCA)7Vle page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene consists of the human wild-type alpha-synuclein cDNA under the control of the tetracycline responsive promoter. Alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression. (J:156801)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156801 Lim Y, et al., Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol. 2010 Jan;221(1):86-97
• All: 2 reference(s)