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Nrp1tm1.1Cruh
Targeted Allele Detail
Nomenclature
Symbol: Nrp1tm1.1Cruh
Name: neuropilin 1; targeted mutation 1.1, Christiana Ruhrberg
MGI ID: MGI:5288597
Synonyms: Nrp1cyto, Nrp1cytodelta
Gene: Nrp1  Location: Chr8:128358604-128503363 bp, + strand  Genetic Position: Chr8, 75.78 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4 base pair insertion (AATT) was inserted into the last exon after the transmembrane domain, shifting the reading frame and preventing translation of the cytoplasmic domain. A floxed neo cassette was inserted after the last exon and then removed by cre-mediated recombination. Immunoblot analysis confirmed the deletion of the cytoplasmic domain and stable expression of the mutant protein in primary cardiac endothelial cells from homozygous mice. (J:176047)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrp1 Mutation:  47 strains or lines available
References
Original:  J:176047 Fantin A, et al., The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development. 2011 Oct;138(19):4185-91
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory