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Targeted Allele Detail
Symbol: Slc6a19tm1Dgen
Name: solute carrier family 6 (neurotransmitter transporter), member 19; targeted mutation 1, Deltagen
MGI ID: MGI:5288516
Gene: Slc6a19  Location: Chr13:73679745-73704865 bp, - strand  Genetic Position: Chr13, 40.14 cM, cytoband C1
Decreased body weight in Slc6a19tm1Dgen mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:175382
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by western blot analysis on small intestine and kidney extracts. (J:175382)
Generation of the Slc6a19tm1Dgen allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a19 Mutation:  2 strains or lines available
Original:  J:175382 Broer A, et al., Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem. 2011 Jul 29;286(30):26638-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory