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Targeted Allele Detail
Symbol: Slc6a19tm1Dgen
Name: solute carrier family 6 (neurotransmitter transporter), member 19; targeted mutation 1, Deltagen
MGI ID: MGI:5288516
Gene: Slc6a19  Location: Chr13:73679745-73700780 bp, - strand  Genetic Position: Chr13, 40.14 cM, cytoband C1
Decreased body weight in Slc6a19tm1Dgen mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:175382
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by western blot analysis on small intestine and kidney extracts. (J:175382)
Generation of the Slc6a19tm1Dgen allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a19 Mutation:  27 strains or lines available
Original:  J:175382 Broer A, et al., Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem. 2011 Jul 29;286(30):26638-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory