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Atxn3tm1.1(ATXN3)Mfig
Targeted Allele Detail
Nomenclature
Symbol: Atxn3tm1.1(ATXN3)Mfig
Name: ataxin 3; targeted mutation 1.1, Maciej Figiel
MGI ID: MGI:5288414
Synonyms: K300
Gene: Atxn3  Location: Chr12:101918901-101958246 bp, - strand  Genetic Position: Chr12, 51.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175960
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Atxn3tm1.1(ATXN3)Mfig expresses 1 gene
 
Mutation detailsExons 2 and 3 were replaced with the human cDNA corresponding to exons 2 through 11 with 69 CAG repeats found in a patient with SCA3 (Spinocerebellar ataxia 3). A floxed neo cassette was removed by cre-mediated recombination. (J:175960)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atxn3 Mutation:  12 strains or lines available
References
Original:  J:175960 Switonski PM, et al., Mouse ataxin-3 functional knock-out model. Neuromolecular Med. 2011 Mar;13(1):54-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory