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Lmx1atm1Tpe
Targeted Allele Detail
Nomenclature
Symbol: Lmx1atm1Tpe
Name: LIM homeobox transcription factor 1 alpha; targeted mutation 1, Thomas Perlmann
MGI ID: MGI:5287978
Gene: Lmx1a  Location: Chr1:167689237-167848741 bp, + strand  Genetic Position: Chr1, 75.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175535
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1and an ApaLI site and floxed neo cassette was inserted 288 bp downstream of exon 2 via homologous recombination. (J:175535)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1a Mutation:  10 strains or lines available
References
Original:  J:175535 Deng Q, et al., Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory