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Gt(ROSA)26Sortm4Mgn
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm4Mgn
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Mark A Magnuson
MGI ID: MGI:5287870
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (RMCE-ready, Reporter)
Mutation:    Insertion
 
Mutation detailsRecombinase mediated cassette exchange (RMCE) replaced the selection cassettes in Gt(ROSA)26Sortm1Mgn with the 5'UTR Xenopus beta-globin translation enchancer, citrine fluorescent protein (YFP), beta-globin intron, polyadenylation sequence, and an FRT-flanked neo cassette. (J:174255)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  501 strains or lines available
References
Original:  J:174255 Chen SX, et al., Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech. 2011 Jul-Aug;4(4):537-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory