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Akap12tm1(KOMP)Mbp
Targeted Allele Detail
Nomenclature
Symbol: Akap12tm1(KOMP)Mbp
Name: A kinase (PRKA) anchor protein (gravin) 12; targeted mutation 1, Mouse Biology Program, UCDavis
MGI ID: MGI:5287737
Gene: Akap12  Location: Chr10:4266380-4359470 bp, + strand  Genetic Position: Chr10, 2.06 cM
Mutation
origin
Mutant Cell Lines:  DEPD00574_1_A09, DEPD00574_1_A10, DEPD00574_1_A11, DEPD00574_1_A12, DEPD00574_1_B09, DEPD00574_1_B10, DEPD00574_1_B11, DEPD00574_1_B12, DEPD00574_1_C09, DEPD00574_1_C10, DEPD00574_1_C11, DEPD00574_1_C12, DEPD00574_1_D09, DEPD00574_1_D10, DEPD00574_1_D11, DEPD00574_1_D12, DEPD00574_1_E09, DEPD00574_1_E11, DEPD00574_1_E12, DEPD00574_1_G09, DEPD00574_1_G10, DEPD00574_1_G11, DEPD00574_1_G12, DEPD00574_1_H09, DEPD00574_1_H11, DEPD00574_1_H12
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 2141 starting at position 4353018 and ending at position 4355159 of Chromosome 10 (Genome Build GRCm38). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Akap12 Mutation:  156 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory