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Hoxa1tm8.2Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxa1tm8.2Mrc
Name: homeobox A1; targeted mutation 8.2, Mario R Capecchi
MGI ID: MGI:5287662
Synonyms: Hoxa1delta
Gene: Hoxa1  Location: Chr6:52155590-52158317 bp, - strand  Genetic Position: Chr6, 25.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175781
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and EcoRI siter were inserted 200 bp upstream of the transcription initiation site and a loxP site, EcoRI site, and FRT flanked neo cassette were inserted36 bp downstream of the stop codon via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 1 and 2. (J:175781)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:  7 strains or lines available
References
Original:  J:175781 Makki N, et al., Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol. 2011 Sep 15;357(2):295-304
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory