Polr2a^tm1Og
Targeted Allele Detail

Summary

• Symbol: Polr2a^tm1Og
• Name: polymerase (RNA) II (DNA directed) polypeptide A; targeted mutation 1, Stephen O'Gorman
• MGI ID: MGI:5287203
• Synonyms: P2Bc
• Gene: Polr2a Location: Chr11:69624823-69649459 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B1-C
• Alliance: Polr2a^tm1Og page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67932
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The conditional allele (P2Bc) was generated by inserting a loxP-flanked neo cassette and a beta-galactosidase sequence into the first exon of the locus coding for the large subunit of RNA polymerase II. Cre-mediated recombination removes the intervening sequence, creating a recombined reporter allele (P2Br) that expresses beta-galactosidase. (J:67932)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polr2a Mutation: 92 strains or lines available

References

• Original: J:67932 O'Gorman S, et al., Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14602-7
• All: 3 reference(s)