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Transposon induced Allele Detail
Symbol: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Name: serine peptidase inhibitor, Kazal type 5; transposon insertion 1498, Paul A Overbeek
MGI ID: MGI:5286986
Synonyms: OVE1498
Gene: Spink5  Location: Chr18:43963235-44022501 bp, + strand  Genetic Position: Chr18, 23.74 cM
Strain of Origin:  FVB/N
Allele Type:    Transposon induced
Mutations:    Insertion, Intergenic deletion
Mutation detailsA transposon transgene containing mouse Pgk2 driving expression of sleeping beauty 10 (SB10) and a mouse tyrosinase minigene driven by a Tyr enhancer flanked by Sleeping Beauty inverted repeats (termed pT-Tybs-3'E) were co-injected with a Pgk2 driven SB10. In line 1498, transposon and transposase co-integration results in a 66.8 kb deletion containing the coding exons of the targeted gene and none of the coding regions of the genes flanking the integration site. RT-PCR confirmed the absence of transcript expression at P0 skin cDNA. (J:93050)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spink5 Mutation:  23 strains or lines available
Original:  J:93050 Yang T, et al., Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 1;18(19):2354-8
All:  1 reference(s)

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MGI 6.03
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