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Chemically induced Allele Detail
Symbol: Nrg1m1Yzcm
Name: neuregulin 1; mutation 1, Yangzhou University Comparative Medicine Center
MGI ID: MGI:5285952
Synonyms: Nrg1Dp1
Gene: Nrg1  Location: Chr8:31814551-32884029 bp, - strand  Genetic Position: Chr8, 18.75 cM
Dilated pupils in Nrg1m1Yzcm/Nrg1+ and Nrg1m1Yzcm/Nrg1m1Yzcm mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU mutagenesis induced a G to A transition in the 5' splice donor site downstream of exon 59. RT-PCR confirmed the expression of multiple transcripts of different lengths. (J:175524)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  14 strains or lines available
Original:  J:175524 Chen B, et al., An ENU-Induced Mutation of Nrg1 Causes Dilated Pupils and a Reduction in Muscarinic Receptors in the Sphincter Pupillae. PLoS One. 2011;6(9):e25176
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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