Slc39a8^tm1.1Dwn
Targeted Allele Detail

Summary

• Symbol: Slc39a8^tm1.1Dwn
• Name: solute carrier family 39 (metal ion transporter), member 8; targeted mutation 1.1, Daniel W Nebert
• MGI ID: MGI:5285694
• Gene: Slc39a8 Location: Chr3:135531040-135594333 bp, + strand Genetic Position: Chr3, 63.04 cM
• Alliance: Slc39a8^tm1.1Dwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174970
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 316bp downstream of exon 6 in intron 6. A loxP and Frt flanked neomycin selection cassette were inserted in intron 3. The neo selection cassette was subsequently removed by crossing to mice expressing flp recombinase. This left exons 4, 5, and 6 flanked by loxP sites. However, cre recombinase failed to excise the floxed exons in living mice although excision succeeded in cultured cells. (J:174970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a8 Mutation: 43 strains or lines available

References

• Original: J:174970 Wang B, et al., Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn(2)/(HCO) transporter expression. Biochem Biophys Res Commun. 2011 Jul 1;410(2):289-94
• All: 2 reference(s)