Slc39a8^tm1Dwn
Targeted Allele Detail

Summary

• Symbol: Slc39a8^tm1Dwn
• Name: solute carrier family 39 (metal ion transporter), member 8; targeted mutation 1, Daniel W Nebert
• MGI ID: MGI:5285693
• Synonyms: Slc39a8(neo)
• Gene: Slc39a8 Location: Chr3:135531040-135594333 bp, + strand Genetic Position: Chr3, 63.04 cM
• Alliance: Slc39a8^tm1Dwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174970
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 316bp downstream of exon 6 in intron 6. A loxP and Frt flanked neomycin selection cassette were inserted in intron 3. mRNA levels were dramitically reduced in homozygotes and Western blot analysis also indicated reduced protein. (J:174970)

Expression

In Mice Carrying this Mutation:

79 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a8 Mutation: 43 strains or lines available

References

• Original: J:174970 Wang B, et al., Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn(2)/(HCO) transporter expression. Biochem Biophys Res Commun. 2011 Jul 1;410(2):289-94
• All: 7 reference(s)