Met^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Met^tm1.1Ics
• Name: met proto-oncogene, receptor tyrosine kinase; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5285633
• Synonyms: Del-Met^LacZ
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174591
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a loxP site, duplicated exon 12, and a neo cassette with 3 polyadenylation sequences and a 3' loxP site was inserted upstream of exon 12. An IRES, nuclear localization sequence, and lacZ gene with a polyadenlylation sequence were inserted downstream of exon 12. Cre-mediated recombination removed the neo/STOP cassette. (J:174591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Met Mutation: 81 strains or lines available

References

• Original: J:174591 Lamballe F, et al., Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. 2011 Aug 3;31(31):11144-58
• All: 1 reference(s)