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Adamts5tm2.2Lex
Targeted Allele Detail
Nomenclature
Symbol: Adamts5tm2.2Lex
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); targeted mutation 2.2, Lexicon Genetics
MGI ID: MGI:5285450
Synonyms: ts5-
Gene: Adamts5  Location: Chr16:85858157-85901125 bp, - strand  Genetic Position: Chr16, 48.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175366
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2, which encodes part of the zinc binding domain. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the neo cassette. (J:175366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts5 Mutation:  4 strains or lines available
References
Original:  J:175366 Malfait AM, et al., ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010 Apr;18(4):572-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory