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Targeted Allele Detail
Symbol: Cdkn1atm1Hpw
Name: cyclin-dependent kinase inhibitor 1A (P21); targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:5285186
Synonyms: p21FLuc
Gene: Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:174375
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA construct containing part of exon 2, a codon-optimized firefly luciferase gene, and floxed neo cassette was inserted upstream of exon 2. Cre-mediated recombination removed the neo cassette. (J:175772)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  57 strains or lines available
Original:  J:174375 Wang YV, et al., Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1;25(13):1426-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory