Cdkn1a^tm1Hpw
Targeted Allele Detail

Summary

• Symbol: Cdkn1a^tm1Hpw
• Name: cyclin dependent kinase inhibitor 1A; targeted mutation 1, Helen Piwnica-Worms
• MGI ID: MGI:5285186
• Synonyms: p21^FLuc
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^tm1Hpw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174375
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct containing part of exon 2, a codon-optimized firefly luciferase gene, and floxed neo cassette was inserted upstream of exon 2. Cre-mediated recombination removed the neo cassette. (J:175772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 60 strains or lines available

References

• Original: J:174375 Wang YV, et al., Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1;25(13):1426-38
• All: 4 reference(s)