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Targeted Allele Detail
Symbol: Trpm2tm1.1Alp
Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1.1, Anne-Laure Perraud
MGI ID: MGI:5284866
Synonyms: TRPM2delta19/20
Gene: Trpm2  Location: Chr10:77907722-77970563 bp, - strand  Genetic Position: Chr10, 39.72 cM
Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:174397
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 19 and 20 were floxed by inserting a floxed neo cassette into intron 18 and an additional loxP site in intron 20. Cre-mediated recombination removed exons 19 and 20 and the neo cassette. The absence of transcripts containing exon 20 was confirmed by RT-PCR on brain extracts. (J:174397)
Generation of the Trpm2tm1.1Alp allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpm2 Mutation:  35 strains or lines available
Original:  J:174397 Knowles H, et al., Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11578-83
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory