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Trpm2tm1.1Alp
Targeted Allele Detail
Nomenclature
Symbol: Trpm2tm1.1Alp
Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1.1, Anne-Laure Perraud
MGI ID: MGI:5284866
Synonyms: TRPM2delta19/20
Gene: Trpm2  Location: Chr10:77907722-77970563 bp, - strand  Genetic Position: Chr10, 39.72 cM
Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174397
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Generation of the Trpm2tm1.1Alp allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpm2 Mutation:  5 strains or lines available
References
Original:  J:174397 Knowles H, et al., Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11578-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory