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Pax7tm1(cre/ERT2)Gaka
Targeted Allele Detail
Nomenclature
Symbol: Pax7tm1(cre/ERT2)Gaka
Name: paired box 7; targeted mutation 1, Gabrielle Kardon
MGI ID: MGI:5141477
Gene: Pax7  Location: Chr4:139737062-139833528 bp, - strand  Genetic Position: Chr4, 70.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174914
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn IRES-cre/ERT2 and an FRT flanked neomycin selection cassette were inserted 8 bp after the endogenous stop codon. The selection cassette was subsequently removed by crossing to a Gt(ROSA)26Sortm1(FLP1)Dym mouse line. Endogenous gene function is preserved. (J:174914)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax7     Summary of all recombinase alleles driven by Pax7.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax7 Mutation:  27 strains or lines available
References
Original:  J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory