Tg(H2-K^b-NFKB2*)808Hfdg
Transgene Detail

Summary

• Symbol: Tg(H2-K^b-NFKB2*)808Hfdg
• Name: transgene insertion 808, Han-Fei Ding
• MGI ID: MGI:5141435
• Synonyms: p80HT, p80HT_808
• Transgene: Tg(H2-K^b-NFKB2*)808Hfdg Location: unknown
• Alliance: Tg(H2-K^b-NFKB2*)808Hfdg page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K^b-NFKB2*)808Hfdg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKB2 (4791)

  Nfkb2

  (MGI:1099800)

• Mutation details: The human p80HT coding sequence was amplified by PCR, using a human fetus Marathon-ready cDNA library (Clontech) as the template and specific primers based on the published p80HT sequence (GenBank U09609), and cloned into pHSE3', a vector containing an H-2K^b promoter and an immunoglobulin mu chain enhancer for transgene expression in lymphocytes. Line 808 was generated. (J:123872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:123872 Zhang B, et al., NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Blood. 2007 Jul 15;110(2):743-51
• All: 1 reference(s)