Tg(TcraTcrb)2H6Lwn
Transgene Detail

Summary

• Symbol: Tg(TcraTcrb)2H6Lwn
• Name: transgene insertion 2H6, Li Wen
• MGI ID: MGI:5141276
• Synonyms: 2H6 TCR transgenic
• Transgene: Tg(TcraTcrb)2H6Lwn Location: unknown
• Alliance: Tg(TcraTcrb)2H6Lwn page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraTcrb)2H6Lwn expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The transgene contains the cloned regulatory/immunosuppressive T cell line (designated 2H6) from the pancreatic lymph nodes of a diabetic NOD mouse that specifically recognizes the insulin B chain peptide 12-25 or 9-23 (2H6 regulatory TCRalpha (Valpha6 (Valpha6/Jalpha45/Calpha)) and TCRbeta (Vbeta14 (Vbeta14/Dbeta1.1Jbeta2.3Cbeta2))). (J:108964)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:108964 Du W, et al., TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest. 2006 May;116(5):1360-70
• All: 2 reference(s)